Buy MOTS-c 40mg Online

MOTS-c (CAS 1627580-64-6, molecular weight 2174.64 Da) is a 16-residue peptide with the sequence Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg, and what makes it unusual is where its gene lives. It is encoded not in nuclear DNA but within the 12S ribosomal RNA region of the mitochondrial genome — a short open reading frame inside a gene that was assumed to code only for structural RNA. That places MOTS-c in a small class of mitochondrial-derived peptides through which the organelle signals outward to the rest of the cell, effectively reversing the usual direction of communication. Its principal reported action is activation of AMP-activated protein kinase, positioning it as an insulin sensitiser and a regulator of glucose handling in skeletal muscle. It also interacts with the folate-methionine cycle, where inhibition of that pathway raises AICAR, an endogenous AMPK activator, giving a plausible route from the peptide to the kinase. Under metabolic stress MOTS-c translocates to the nucleus and influences expression of nuclear stress-response genes directly. Circulating levels decline with age.