Buy SLU-PP-332 100mg x30 Capsules Online

SLU-PP-332 is not a peptide — it is a synthetic small molecule (C18H14N2O2, molecular weight 290.32 Da, CAS 303760-60-3) that agonises all three estrogen-related receptors: ERR-alpha, ERR-beta and ERR-gamma, with reported EC50 values of 98nM, 230nM and 430nM respectively. Despite the name, ERRs do not bind estrogen; they are orphan nuclear receptors that share sequence homology with the estrogen receptor but sit at the transcriptional hub of oxidative metabolism. Working with the coactivator PGC-1-alpha, they drive expression of the gene programme for mitochondrial biogenesis, fatty acid oxidation and electron transport chain assembly. Endurance training activates that same ERR/PGC-1-alpha axis, which is the basis for describing the compound as an exercise mimetic. Work from the Burris group at Saint Louis University reports increased mitochondrial function and cellular respiration in skeletal muscle cell lines, and reversal of diet-induced metabolic syndrome phenotypes in mice with no change in food intake or activity. It has since been characterised in anti-doping analytical literature for detectability in sport.