Research Specifications

Sequence:: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (Ac-EEMQRRADE-NH2)
INCI Name:: Acetyl Glutamyl Heptapeptide-3
CAS Number:: 868844-74-0
Molecular Weight:: 1075.2 Da
Form:: Lyophilized powder
Purity:: ≥98% (HPLC verified)
Storage:: −20°C long-term / 4°C up to 4 weeks

SNAP-8 10mg

Name: SNAP-8 10mg
SKU: PG-1109
Price: 40.5 USD
Availability: InStock

Acetyl Octapeptide-3 — an 8-amino acid SNARE complex mimic studied for expression wrinkle reduction via neuromuscular junction modulation.

$40.50In Stock

Buy Now

>98% Purity Lyophilized Powder Fast Shipping

Pharmacology

Compound action

SNARE Complex Inhibition at the Neuromuscular Junction

SNAP-8 (Acetyl Glutamyl Heptapeptide-3, CAS: 868844-74-0) is a synthetic octapeptide (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2) that mimics the N-terminal end of SNAP-25, a key protein in the SNARE (Soluble NSF Attachment Protein REceptor) complex responsible for synaptic vesicle docking and neurotransmitter release. At the neuromuscular junction, SNARE complex assembly drives acetylcholine vesicle fusion — initiating muscle contraction. SNAP-8 competes with native SNAP-25 for SNARE complex formation, modulating the release of catecholamines from nerve endings. Reduced neurotransmitter release → reduced muscle contraction frequency → reduced mechanical stress on overlying dermis from repetitive facial expressions. Studies at 10% concentration in topical formulations have shown measurable reduction in forehead wrinkle depth as assessed by optical profilometry after 4–28 days of twice-daily application. Molecular weight: 1075.2 Da.

Research FAQ

What is SNAP-8?

SNAP-8 (Acetyl Octapeptide-3) is a synthetic 8-amino acid peptide that mimics the N-terminal region of SNAP-25, a protein in the SNARE complex at the neuromuscular junction. It is studied for its potential to modulate catecholamine release and reduce expression-line formation via reduced NMJ signaling frequency.

How does SNAP-8 differ from Botulinum toxin?

Botulinum toxin cleaves SNAP-25 irreversibly, completely blocking SNARE complex assembly and paralyzing the muscle. SNAP-8 competes reversibly with native SNAP-25 for SNARE complex formation — a modulatory rather than blocking mechanism. Research models suggest partial reduction in signaling rather than complete inhibition, preserving normal muscle tone.

What concentration is used in SNAP-8 research?

In vitro studies typically use concentrations of 1–10 μM in cell culture models. Topical formulation research has used concentrations of 4–10% w/w in emulsion vehicles. The 45mg vial provides substantial supply for multiple research applications.

Trial Data Points

SNARE Complex Modulation

SNAP-8 targets the SNARE complex — the molecular machinery that drives synaptic vesicle fusion and neurotransmitter release. By competing with native SNAP-25 for complex assembly, it modulates acetylcholine release at the neuromuscular junction without blocking it entirely, preserving normal muscle function while reducing high-frequency contraction patterns.

Expression Line Research

The primary research application for SNAP-8 is expression wrinkle formation. Repetitive facial muscle contractions — squinting, frowning, smiling — create mechanical stress on the dermis that forms expression lines over time. SNAP-8 models investigate whether reducing contraction frequency via NMJ modulation can reduce this mechanical stress.

Topical Formulation Studies

Unlike most research peptides which are administered parenterally, SNAP-8 has been studied in topical delivery models. Small molecular weight (1075 Da) and amphiphilic character support skin penetration studies. Research has investigated encapsulation in liposomal and nanoparticle carriers for enhanced dermal delivery.

Research Use Only. This product is intended for in-vitro laboratory research only. Not for human consumption, injection, or therapeutic use. Not medical advice. Always consult applicable regulations in your jurisdiction.