Buy SNAP-8 10mg Online

SNAP-8 (Acetyl Glutamyl Heptapeptide-3, CAS: 868844-74-0) is a synthetic octapeptide (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2) that mimics the N-terminal end of SNAP-25, a key protein in the SNARE (Soluble NSF Attachment Protein REceptor) complex responsible for synaptic vesicle docking and neurotransmitter release. At the neuromuscular junction, SNARE complex assembly drives acetylcholine vesicle fusion — initiating muscle contraction. SNAP-8 competes with native SNAP-25 for SNARE complex formation, modulating the release of catecholamines from nerve endings. Reduced neurotransmitter release → reduced muscle contraction frequency → reduced mechanical stress on overlying dermis from repetitive facial expressions. Studies at 10% concentration in topical formulations have shown measurable reduction in forehead wrinkle depth as assessed by optical profilometry after 4–28 days of twice-daily application. Molecular weight: 1075.2 Da.