Buy Tesamorelin 20mg Online

Tesamorelin (CAS 218949-48-5, C221H366N72O67S, molecular weight 5135.87 Da) is a fully synthetic 44-residue peptide amide built on the human growth hormone-releasing hormone scaffold, GHRH(1-44), with a trans-3-hexenoyl group attached to the alpha-amino group of the N-terminal tyrosine. That acylation is the defining structural edit: native GHRH is cleaved within minutes by dipeptidyl peptidase-4 at the N-terminus, and the hexenoyl cap blocks the cleavage site while raising lipophilicity. The compound binds the GHRH receptor on somatotroph cells in the anterior pituitary, a class B G-protein-coupled receptor, and stimulates synthesis and release of the body own growth hormone. That distinction matters: tesamorelin does not supply growth hormone, it acts one step upstream, so release remains pulsatile and stays under the negative feedback control of somatostatin and circulating IGF-1. Exogenous growth hormone overrides that feedback; a secretagogue does not. Tesamorelin was approved by the FDA in November 2010 for HIV-associated lipodystrophy, where the reduction was specifically in visceral rather than subcutaneous adipose tissue.