Buy Tesofensine 500mcg x30 Capsules Online

Tesofensine (CAS 402856-42-2, C17H23Cl2NO, molecular weight 328.28 Da, originally coded NS2330) is a small-molecule inhibitor of the presynaptic transporters for noradrenaline, dopamine and serotonin. Blocking reuptake at all three leaves more of each neurotransmitter in the synaptic cleft for longer, raising monoaminergic tone rather than acting as a receptor agonist directly. It began life as a candidate for Parkinson disease and Alzheimer disease, where it failed on efficacy, and the appetite suppression seen in those trials is what redirected it toward obesity research. Mechanistic work in diet-induced obese rats by Axel and colleagues, published in Neuropsychopharmacology, found the appetite suppression is not a direct action of the transporters but an indirect one: raised synaptic noradrenaline and dopamine stimulate alpha-1 adrenoceptor and dopamine D1 receptor pathways, and blocking either receptor attenuates the effect. The dichlorophenyl group in the structure is part of the molecule itself, not a hydrochloride salt — worth noting when reading the formula, which contains two chlorine atoms by design.