Research Specifications
- Sequence:
- Gly-His-Lys (with Cu²⁺ coordination)
- Full Name:
- Glycyl-L-Histidyl-L-Lysine:copper(2+)
- CAS Number:
- 49557-75-7
- Molecular Weight:
- 340.38 Da (free tripeptide)
- Form:
- Lyophilized powder
- Purity:
- ≥98% (HPLC verified)
- Storage:
- −20°C long-term / 4°C up to 4 weeks reconstituted
GHK-Cu 50mg
Glycyl-L-Histidyl-L-Lysine copper complex — the copper-binding tripeptide that modulates expression of over 4,000 human genes involved in collagen synthesis, wound healing, and cellular repair.
Copper Delivery & Gene Expression Modulation
GHK-Cu (Glycyl-L-Histidyl-L-Lysine copper complex, CAS: 49557-75-7) is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine — concentrations decline significantly with age (~200ng/mL at age 20 to ~80ng/mL by age 60). GHK-Cu modulates the expression of over 4,000 human genes, promoting wound healing and remodeling genes while downregulating inflammatory and oncogenic pathways. As a copper chaperone, it delivers Cu²⁺ to cuproenzymes including lysyl oxidase (collagen/elastin crosslinking) and superoxide dismutase (SOD1/SOD3). Fibroblast studies show increased synthesis of collagen types I, III, and IV, metalloproteinase activation for old collagen breakdown, and TIMP-1/2 upregulation to prevent excessive matrix degradation. Molecular weight: 340.38 Da (free tripeptide).
Research Highlights
Collagen & Skin Matrix Research
GHK-Cu stimulates collagen types I, III, and IV synthesis by fibroblasts, activates metalloproteinases for old collagen breakdown, and upregulates TIMP-1/2 to prevent excessive matrix degradation. In vitro studies show increased dermal thickness and tensile strength in treated fibroblast models.
Wound Healing
GHK-Cu accelerates wound healing in multiple animal models through angiogenesis promotion, keratinocyte migration, and anti-oxidant defense via SOD activation. It has been studied in human clinical trials for wound and ulcer healing, with demonstrated improvements in healing rate and tissue quality.
Anti-Aging Gene Expression
Microarray analysis shows GHK-Cu reverses gene expression signatures of aged skin — upregulating repair, remodeling, and mitochondrial genes while downregulating inflammatory and oncogenic pathways. Pickart's foundational research identified 4,000+ gene targets, covering approximately one-third of the human genome.
Research FAQ
What is GHK-Cu researched for?
Why do GHK-Cu levels decline with age?
How should GHK-Cu 50mg be reconstituted?
Research Use Only. This product is intended for in-vitro laboratory research only. Not for human consumption, injection, or therapeutic use. Not medical advice. Always consult applicable regulations in your jurisdiction.
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GHK-Cu 50mg
$50.00