Buy SS-31 50mg Online

This is the 50mg vial of the same tetrapeptide as the 25mg listing, and the property worth dwelling on is how something this small gets where it is going. Most compounds aimed at mitochondria are built around a lipophilic cation — triphenylphosphonium is the classic choice — which accumulates in the matrix because the inner membrane carries a large negative potential. That approach has a flaw: in damaged mitochondria the membrane potential has collapsed, so the compound stops accumulating precisely in the organelles that need it most. SS-31 does not work that way. Its alternating aromatic and basic residues let it partition into the inner membrane independently of potential, which means uptake holds up in depolarised, dysfunctional mitochondria. The molecule is also small enough at 639.78 Da to move through membranes unassisted, and its D-arginine at the N-terminus resists the proteases that would otherwise dismantle a short peptide within minutes. Between them these three features — potential-independent targeting, low mass, and protease resistance — are what make a four-residue peptide a viable mitochondrial agent rather than a curiosity.