Research Specifications
- Sequence:
- H-Ala-Glu-Asp-Gly-OH
- CAS Number:
- 307297-39-8
- Molecular Weight:
- 482.46 Da
- Form:
- Lyophilized powder
- Purity:
- ≥98% (HPLC verified)
- Storage:
- −20°C long-term / 4°C up to 4 weeks reconstituted
- Reconstitution:
- Bacteriostatic water or sterile saline
Epithalon 50mg
Tetrapeptide Ala-Glu-Asp-Gly — Khavinson's pineal bioregulator. Researched for telomerase activation, telomere elongation, and circadian rhythm restoration in aged tissue models.
Telomerase Activation & Pineal Bioregulation
Epithalon (Epitalon, tetrapeptide Ala-Glu-Asp-Gly, CAS: 307297-39-8) is a synthetic version of the natural peptide Epithalamin isolated from bovine pineal gland extracts by Vladimir Khavinson. Its primary researched mechanism involves activation of telomerase (hTERT) — the enzyme that extends telomere length. Telomerase is active in germline and stem cells but silenced in most somatic cells; Epithalon appears to reactivate hTERT expression in fibroblasts and lymphocytes in vitro, with studies showing 24–33% telomere elongation at nanomolar concentrations. The proposed mechanism involves histone H3/H4 acetylation at the hTERT promoter — epigenetic chromatin remodeling rather than direct enzyme activation. Epithalon also regulates melatonin synthesis in the pineal gland and shows antioxidant properties via free radical scavenging. Molecular weight: 482.46 Da.
Research Highlights
Telomerase Activation Research
Khavinson et al. published in vitro studies showing Epithalon at nanomolar concentrations activates hTERT expression in human fetal fibroblasts, producing measurable telomere elongation (24–33%). The proposed mechanism involves epigenetic chromatin remodeling — histone H3/H4 acetylation at the hTERT promoter — rather than direct enzyme activation.
Pineal Gland & Melatonin Regulation
Animal studies show Epithalon normalizes the age-related decline in pineal melatonin synthesis. In aged rodents, the compound restored nightly melatonin surges to levels observed in young adults, with associated improvements in sleep architecture and circadian rhythm markers — a neuroendocrine action distinct from other anti-aging peptides.
Longevity Research Findings
Multiple rodent studies from Khavinson's lab reported 10–16% lifespan extension in treated groups vs controls, alongside reduced incidence of spontaneous tumors. Foundational research comes primarily from Khavinson's laboratory in St. Petersburg across 40+ published studies — independent Western replication is limited.
Research FAQ
What is Epithalon?
How does Epithalon differ from other anti-aging peptides?
What reconstitution volume is used for Epithalon 50mg?
Research Use Only. This product is intended for in-vitro laboratory research only. Not for human consumption, injection, or therapeutic use. Not medical advice. Always consult applicable regulations in your jurisdiction.
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Epithalon 50mg
$139.99